Extracellular apparent diffusion in rat brain
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چکیده
منابع مشابه
Extracellular apparent diffusion in rat brain.
The apparent diffusion coefficients (ADCs) of a series of markers concentrated in the extracellular space of normal rat brain were measured to evaluate, by inference, the ADC of water in the extracellular space. The markers (mannitol, phenylphosphonate, and polyethylene glycols) are defined as "compartment selective" because tissue culture experiments demonstrate some leakage into the intracell...
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The apparent diffusion coefficient (ADC) of Na(+) was determined in live rat brain. The brain extracellular-to-intracellular Na(+) content ratio is approximately 8:2, which is the inverse of that for water in these spaces. Consequently, the ADC of Na(+) is primarily affected by motion in the extracellular space, and Na(+) can be viewed as a reporter molecule for motion in that space. Likewise, ...
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Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules in the brain. Deviations from the equation reveal loss of molecules across the blood-brain barrier, through cellular uptake, binding, or other mechanisms. Early diffusion measurements used radiolabe...
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Extracellular space (ECS) is a major channel transporting biologically active molecules and drugs in the brain. Diffusion-mediated transport of these substances is hindered by the ECS structure but the microscopic basis of this hindrance is not fully understood. One hypothesis proposes that the hindrance originates in large part from the presence of dead-space (DS) microdomains that can transie...
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Molecular diffusion in brain extracellular space (ECS) is primarily controlled by interactions with the geometry and the interstitial matrix. Both factors increase λ, the tortuosity, a measure of hindrance to diffusion where λ2 = D/D∗ with D the free diffusion coefficient and D∗ the effective diffusion coefficient in brain [1]. Geometry lengthens diffusion paths or creates holdup in local voids...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2001
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.1108